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Could Human Herpesvirus 6 Be A Trigger Of Your Autoimmune Disease

Updated: May 16


Autoimmune diseases are complex, chronic conditions in which the body’s immune system mistakenly attacks its own tissues. While the exact cause of autoimmune disease remains unclear, emerging research points to a combination of genetic predisposition, environmental triggers, and immune dysregulation.

One area of growing interest is the role of viral infections in the onset and progression of autoimmune disease—particularly Human Herpesvirus 6 (HHV-6). At The Autoimmune Clinic, we work with individuals to investigate root causes like these and offer personalised support to help you regain control of your health.


What is Human Herpesvirus 6 (HHV-6)?


HHV-6 is a widespread virus that belongs to the herpesvirus family. Nearly all individuals are infected with HHV-6 by early childhood. There are two known variants:

  • HHV-6A: Less well understood but suspected to be more neuroinvasive.

  • HHV-6B: Commonly associated with roseola infantum (a mild childhood illness).


Following the initial infection, HHV-6 typically becomes latent, remaining dormant within the body. However, certain triggers—such as stress, immunosuppression, toxin exposure, or other infections—can cause the virus to reactivate, potentially leading to long-term immune dysfunction.


HHV-6 and Autoimmune Disease: Exploring the Connection


1. Molecular Mimicry

HHV-6 shares structural similarities with human proteins, a phenomenon known as molecular mimicry. This can mislead the immune system into targeting both the virus and healthy tissue, setting the stage for autoimmune responses. Over time, this may contribute to chronic inflammation and tissue damage.


2. Immune Dysregulation

The virus has been shown to interfere with normal immune signalling pathways. HHV-6 can directly infect immune cells such as T cells and dendritic cells, impairing immune regulation. This disturbance may not only weaken defences but also trigger inappropriate immune responses, characteristic of autoimmune diseases.


3. Reactivation and Disease Flares

In individuals with autoimmune disease, reactivation of HHV-6 has been observed during periods of symptom worsening or disease flares. This suggests the virus may not only contribute to onset but also worsen disease activity once autoimmunity is established.


4. Impact on Immune Tolerance

HHV-6 may also compromise the mechanisms that allow the immune system to tolerate the body’s own tissues—known as immune tolerance. Disruption of this balance may lead to loss of self-tolerance, a critical hallmark in autoimmune disease development.


Conditions Potentially Linked to HHV-6

Research has linked HHV-6 to several autoimmune and neuroinflammatory conditions, including:


Although this connection is still under active investigation, the cumulative evidence suggests a meaningful relationshipbetween HHV-6 and immune dysfunction.


Taking a Root-Cause Approach to Autoimmunity

At The Autoimmune Clinic, we understand that each person’s health journey is unique. Viral triggers such as HHV-6 are just one piece of a complex puzzle that may also involve gut health, environmental toxins, mould exposure, hormone imbalances, and more.

Our clinic specialises in working with clients to identify hidden triggers, understand immune system imbalances, and design personalised, evidence-informed plans for long-term health improvement.


Ready to Take Control of Your Health?

If you're living with an autoimmune condition—or suspect that a virus like HHV-6 could be contributing to your symptoms—we’re here to help.


Book a free discovery call to speak with a practitioner about your situation, and learn how our tailored approach may help uncover the root causes behind your symptoms.


Visit: www.theautoimmuneclinic.co.uk Book a discovery call today and take the first step towards clarity, confidence, and better health.

 
 
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